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Task 11.21

Describe examples of cellular communication (e.g. what can I look at/describe

bioinformatically?).

Task 11.22

The TMHMM server is used to detect transmembrane motifs in proteins that are partially

located in a membrane. Find the link to it and analyze a matching sequence.

Task 11.23

Locate NucPred/LocSigDB for nuclear localization and analyze a matching sequence.

Task 11.24

Find SignalP for secretion signals in proteins and analyze a matching sequence.

Task 11.25

PROSITE finds motifs in proteins. Find the PROSITE database and analyze a matching

sequence.

Task 11.26

The ELM server outputs all this in bundles. Find this one as well and analyze a matching

sequence.

Task 11.27

The Gene Ontology annotation (GO annotation) brings bioinformatics “order” to a cell.

Learn about the GO annotation and the three classifications used: molecular function,

biological process and cellular compartment.

Task 11.28

Describe how to draw a network in the cell using Cytoscape.

Task 11.29

How to study the drawn network with the BiNGO plugin?

Task 11.30

Using the PlateletWeb database as an example, how can you study a particular cell type?

Perform a simple query, looking through the design (where do I put or insert the antico­

agulant?) and export the network (then you could reconnect the previous network analysis

and mathematical modelling tasks).

11  Design Principles of a Cell